Author

Richard B. Lock

UNSW SydneyORCID 0000-0002-3436-9071Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Ali AfrasiabiiD· 1 shared Alvin FarreliD· 1 shared Anthony C. BryaniD· 1 shared Apexa ModiiD· 1 shared C. Patrick ReynoldsiD· 1 shared Cara E. ToscaniD· 1 shared Carl R. WalkleyiD· 1 shared Casey S. GreeneiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Ali AfrasiabiORCID

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2 papers

Recent·Most cited

Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and SUMOylation Blockade in MDS/AML

Peter Truong, Sylvie Shen, Swapna Mahurkar Joshi, Md Imtiazul Islam, Ling Zhong, Mark J. Raftery, Ali Afrasiabi, Hamid Alinejad‐Rokny, Mary T. H. D. Nguyen, Xiaoheng Zou, Golam Sarower Bhuyan, Chowdhury Hasan Sarowar, Elaheh Sadat Ghodousi, Olivia J. Stonehouse, Sara Mohamed, , John E. Pimanda

This study identifies a synergy between hypomethylating agents and SUMOylation blockade in MDS/AML using CRISPR-Cas9 screening, showing improved therapeutic outcomes in xenograft models.

bioRxiv · Apr 17, 2024 · PreprintMolecular Biology

Genomic profiling of childhood tumor patient-derived xenograft models to enable rational clinical trial design

Jo Lynne Rokita, Komal S. Rathi, Maria Cardenas, Kristen A. Upton, Joy C. Jayaseelan, Katherine L. Cross, Jacob Pfeil, Laura E. Egolf, Gregory P. Way, Alvin Farrel, Nathan M. Kendsersky, Khushbu Patel, Krutika Satish Gaonkar, Apexa Modi, Esther R. Berko, , John M. Maris

This paper genomically characterizes 261 pediatric cancer patient-derived xenograft models to guide rational clinical trial design and drug development.

Cell Reports · Nov 1, 2019Peer-reviewedGenomics