Author
UNSW SydneyORCID 0009-0005-5913-2926Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Golam Sarower Bhuyan, Feng Yan, Mary N.T. Nguyen…·John E. Pimanda
The paper identifies cell-state-specific mechanisms of 5-azacytidine response in myelodysplastic neoplasms, showing distinct differentiation and transcriptional changes in cycling progenitors and quiescent stem cells.
Julie A.I. Thoms, Henry R. Hampton, Priscilla Li Shan Boon…·John E. Pimanda
This study uses single-cell multiomics to show that AZA response in MDS involves hematopoietic regeneration from mutated HSPCs and that AZA-refractive sub-populations contribute to disease progression.
Peter Truong, Sylvie Shen, Swapna Mahurkar Joshi…·John E. Pimanda
This study identifies a synergy between hypomethylating agents and SUMOylation blockade in MDS/AML using CRISPR-Cas9 screening, showing improved therapeutic outcomes in xenograft models.