Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and SUMOylation Blockade in MDS/AML
Peter Truong, Sylvie Shen, Swapna Mahurkar Joshi, Md Imtiazul Islam, Ling Zhong, Mark J. Raftery, Ali Afrasiabi, Hamid Alinejad‐Rokny, Mary T. H. D. Nguyen, Xiaoheng Zou, Golam Sarower Bhuyan, Chowdhury Hasan Sarowar, Elaheh Sadat Ghodousi, Olivia J. Stonehouse, Sara Mohamed, , John E. Pimanda
This study identifies a synergy between hypomethylating agents and SUMOylation blockade in MDS/AML using CRISPR-Cas9 screening, showing improved therapeutic outcomes in xenograft models.
bioRxiv · Apr 17, 2024 · PreprintMolecular Biology