Wayne Vuong

This study identifies residues critical for separating antimicrobial activity from membrane disruption in LL-37 by modulating its dimerization interface.

The paper identifies LL-37 variants that kill gram-negative bacteria without membrane disruption and bacteria that are permeabilized without being killed, suggesting alternative mechanisms of antibacterial activity.

PSMtags enhance peptide detection and sequence identification in proteomics, enabling 9-plexDIA and significantly increasing sample throughput.