Enhanced mouse virulence of mpox virus clade Ib over clade IIb despite genomic changes caused by human-to-human transmission
Alazne R. Unanue, Rocío Martín, Carolina Sánchez, Ana Moraga-Quintanilla, Laura Fernandez del Ama, Pedro J. Sánchez‐Cordón, Antonio Alcamı́, Bruno Hernáez
This study compares the virulence of mpox virus clade Ib and IIb, finding clade Ib is more virulent in mice despite genomic changes from human-to-human transmission.
bioRxiv · Sep 22, 2025 · PreprintMicrobiology