Bruno Hernáez

Non-cyclic dinucleotide STING agonists abrogate MPXV infection

The paper shows non-cyclic dinucleotide STING agonists effectively suppress MPXV infection by bypassing poxin-mediated inhibition, leading to reduced viral replication and improved survival in mice.

Enhanced mouse virulence of mpox virus clade Ib over clade IIb despite genomic changes caused by human-to-human transmission

This study compares the virulence of mpox virus clade Ib and IIb, finding clade Ib is more virulent in mice despite genomic changes from human-to-human transmission.

Viral soluble decoy receptor as a novel treatment for IFN-I triggered diseases

This study explores the use of viral IFN-I binding protein as a therapeutic to neutralize IFN-I and treat autoinflammatory diseases in mouse models.

Attenuation of the 2022 global outbreak monkeypox virus relative to its clade IIb ancestor

This study compares a 2022 MPXV lineage B.1 virus with its clade IIb ancestor A.1, showing attenuated phenotypes including reduced virulence and immune evasion.