Cancer BiologybioRxivPreprint
Development of a Bipyrimidineamide based α-Helix Mimetic Lead Compound for efficient Targeting of MDM2 in Triple-Negative Breast Cancer
Jasmin Linh On, Vitalij Woloschin, Franziska Gier…·Knud Esser
This study develops a bipyrimidineamide-based α-helix mimetic compound, VWK603, which effectively targets MDM2 in TNBC cells with lower toxicity than Nutlin-3a.
DOI 10.1101/2024.03.02.582899