Author

Jason Kuan Han Lai

Max Planck Institute for Heart and Lung ResearchORCID 0000-0002-3476-4733Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:zebrafish· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Didier Y. R. StainieriD· 2 shared Alicia Lardennois· 1 shared Carsten SchelmbaueriD· 1 shared Carsten Tobias KuenneiD· 1 shared Chaitanya DingareiD· 1 shared Constanze HeinzeniD· 1 shared David Simon Kleinhans· 1 shared Geetika Chouhan· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersDevelopmental Biology

Didier Y. R. StainierORCID

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3 papers

Recent·Most cited

Vgll4 Proteins limit Organ Size in Zebrafish through Yap1-Dependent and -Independent Mechanisms

Alicia Lardennois, Veronika Elisabeth Duda, Chaitanya Dingare, Petra A. B. Klemmt, Constanze Heinzen, Lucas Desruelles, Melanie Heyde, David Simon Kleinhans, Thorsten Falk, Carsten Schelmbauer, Olivia Mozolewska, Sofia A. Papadopoulou, Jason Kuan Han Lai, Didier Y. R. Stainier, Virginie Lecaudey

This study shows Vgll4 proteins regulate zebrafish organ size by both enhancing and limiting Yap1 activity in the posterior lateral line primordium.

Communications Biology · Apr 25, 2026Peer-reviewedDevelopmental Biology

DNA-damage induced cell death in yap1;wwtr1 mutant epidermal basal cells

Jason Kuan Han Lai, Pearlyn Jia Ying Toh, Hamizah Ahmad Cognart, Geetika Chouhan, Timothy E. Saunders

The paper shows that DNA damage induces apoptosis in zebrafish yap1-/-;wwtr1-/- epidermal basal cells, with substrate stiffness modulating genomic stress and cell survival.

eLife · May 30, 2022Peer-reviewedDevelopmental Biology

Induction of Interferon-Stimulated Genes and Cellular Stress Pathways by Morpholinos

Jason Kuan Han Lai, Kristina Gagalova, Carsten Tobias Kuenne, Mohamed A. El-Brolosy, Didier Y. R. Stainier

This study identifies interferon-stimulated gene and cellular stress pathway activation in zebrafish morpholino-injected embryos, suggesting morpholinos may trigger innate immune responses.

Developmental Biology · Jun 12, 2019Peer-reviewedGenetics