Timothy E. Saunders

The paper shows that boundary constraints influence the spatial patterning of cell fates during development through a reaction-diffusion model and Wnt signaling.

The paper quantitatively evaluates nine green and eight red fluorophores in Drosophila embryos to identify optimal choices based on bleaching, folding, and imaging conditions.

This study investigates the role of Myomixer (Mymx) in zebrafish myogenesis, showing its dynamic expression and differential requirement during muscle formation and regeneration.

This study investigates how the zebrafish myotome forms a robust 3D structure through a structural transition involving cell rearrangement and mechanical plasticity.

This paper develops a continuum framework to study stress anisotropy in 3D curved biological layers, showing how curvature and cell mechanics lead to irregular cellular shapes like scutoids.

The paper develops a biophysical model to explain how cells align over long distances through interfacial energy constraints, demonstrating its applicability to cell matching in the Drosophila heart.

This study examines the spatiotemporal dynamics of bcd mRNA translation in Drosophila oocytes and embryos, revealing that translation is restricted to the anterior pole and regulated by P bodies.

CellMet extracts 3D shape metrics from cell and tissue segmentations to improve analysis of cell organization in densely packed tissues.

The paper shows that tissue architecture and receptor binding can explain the transition from local to global morphogen diffusion, without needing additional regulatory mechanisms.

The paper shows that Midkine and Ptprz1b regulate Wnt/PCP pathway activity to coordinate midline formation in zebrafish hindbrain development.

This study investigates Bicoid gradient formation in Drosophila embryos, revealing spatially varying dynamic modes that explain the gradient's exponential shape.

The paper shows that DNA damage induces apoptosis in zebrafish yap1-/-;wwtr1-/- epidermal basal cells, with substrate stiffness modulating genomic stress and cell survival.

The paper develops a method to quantify 3D concentration gradients and cellular organisation in curved epithelial tissues using image processing and intensity correction.

This study uses an optogenetic tool to show that Drosophila embryos are most sensitive to Htl over-activation during a specific developmental window, affecting heart morphogenesis.

This study investigates how three internal organs in Drosophila embryos scale with embryo size, finding that the heart scales precisely while the hindgut and VNC show less consistent scaling.

The paper investigates the mechanics of Drosophila ventral nerve cord condensation, revealing oscillatory contractions and coordinated mechanical interactions between neurons and glia.

The paper identifies Pcdh18a-positive tip cells that guide notochord formation in zebrafish through migration and signaling.

The paper shows that lateral inhibition via MpFRH1 miRNA regulates rhizoid cell patterning in Marchantia polymorpha, suggesting independent evolution of this mechanism in land plants.

The paper studies a minimal Rab5 activation network to show how positive feedback leads to bistable switching and how controlling inactive Rab5 populations shapes network responses.

The paper shows that embryonic geometry, not genetics, drives phenotypic variation in decanalized Drosophila embryos by shifting segmentation gene boundaries based on embryonic length.

The paper identifies miR-1010 as a mirtron that works with its host gene SKIP to regulate synaptic homeostasis by modulating nAcRβ2 and CaMKII signaling.

The paper shows Shh signaling drives tissue shear and cell rearrangements in the presomitic mesoderm, contributing to boundary formation.

The paper shows that mutations in different exons of Distal-less (Dll) cause distinct eyespot phenotypes, which are accurately modeled by reaction-diffusion mechanisms.

The paper shows that specific miRNAs buffer genetic variation at certain temperatures during Drosophila embryogenesis, increasing developmental robustness.

The paper uses a fluorescent timer to analyze Bicoid gradient dynamics in Drosophila embryos, revealing parameters consistent with the synthesis-diffusion-degradation model.

This study shows Drosophila embryonic development is temporally robust across a wide temperature range, with species-specific temperature-dependent mechanisms.

The paper investigates how selective filopodia adhesion mediated by adhesion molecules ensures robust cell matching in Drosophila heart development.

The paper combines optogenetics and light-sheet microscopy to study Wnt signaling in Drosophila embryos, showing light-induced inhibition of Wnt signaling and its role in development.

The paper investigates how the morphogen Bicoid's temporal exposure affects cell fate decisions in Drosophila embryos using optogenetic manipulation.