Targeting soluble immunoglobulins ameliorates idiopathic multicentric Castleman disease in a mouse model
David C. Uhlfelder, David Andruszewski, Leon R Amelong…·Ilgiz A. Mufazalov
This paper develops a mouse model of idiopathic multicentric Castleman disease (iMCD) by targeting IL-6 to Foxp3+ Treg cells, showing that reducing soluble immunoglobulin production alleviates disease symptoms and improves survival.