Thomas Topilko

This study identifies ventral pallidal GABAergic neurons as a key population controlling hedonic feeding and obesity in mice through optogenetic and ablation experiments.

The paper proposes spatial and network principles for locomotion generation in the spinal cord using a mouse model and integrates single-cell RNA sequencing with spatial transcriptomics.

This study shows that adolescent nicotine exposure disrupts dopamine circuit development, leading to adult vulnerability to nicotine, which can be reversed by restoring dopamine pathway balance.

The paper studies individual differences in reward-seeking behavior among isogenic mice in a social environment and links these differences to nicotine response and dopaminergic adaptability.

The paper introduces mesoSPIM, an open-source light-sheet microscope initiative for imaging large cleared tissue samples with near-isotropic resolution.