Daniel Kirschenbaum

Mapping Leukocyte Dynamics during Neuroinflammation Identifies Meningeal Monocyte-Derived Macrophages as Drivers of Progressive Disease

This study identifies meningeal monocyte-derived macrophages as drivers of progressive multiple sclerosis using single-cell and spatial transcriptomics.

Quantitative 3D histochemistry reveals region-specific amyloid-β reduction by the antidiabetic drug netoglitazone

This study uses quantitative 3D histochemistry to show that netoglitazone reduces amyloid-beta plaques in specific brain regions of a mouse AD model.

Longitudinal quantitative whole-brain microscopy reveals distinct temporal and spatial efficacies of anti-Aβ therapies

This study uses longitudinal whole-brain imaging to show that anti-Aβ therapies have distinct spatial and temporal efficacies, with polythiophenes showing strong Aβ clearance.

Developmental Divergence of Sensory Stimulus Representation in Cortical Interneurons

The paper identifies a developmental transition in VIP+ and SST+ interneurons in the mouse barrel cortex around P14, where their responses to multi-whisker stimuli diverge and their thalamic inputs shift.

Whole brain optoacoustic tomography reveals strain-specific regional beta-amyloid densities in Alzheimer`s disease amyloidosis models

The paper introduces vMSOT with AOI987 to quantify Aβ deposition in AD mouse models, revealing strain-specific patterns.

The mesoSPIM initiative: open-source light-sheet mesoscopes for imaging in cleared tissue

The paper introduces mesoSPIM, an open-source light-sheet microscope initiative for imaging large cleared tissue samples with near-isotropic resolution.