BioengineeringbioRxivPreprint
Circularization of Single-Stranded DNA Donor Template Unleashes the Power of Non-Viral Gene Delivery for Long-Term HSCs editing
Gil Letort, Aymeric Duclert, Diane Le Clerre…·Julien Valton
This study develops a non-viral gene editing method using circular single-stranded DNA templates and TALEN, showing improved engraftment and long-term gene editing in HSPCs compared to AAV.
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