How Varenicline Works: Identifying Critical Receptor and Ligand-based Interactions
Sheenagh Aiken, Daniele Fiorito, Matthew Harper, Grzegorz Pikus, Juno Underhill, Jacob Murray, Joshua Rawlinson, AnnMarie C. O’Donoghue, Cecilia Gotti, Sarah C. R. Lummis, Teresa Minguez, Franco Viscarra, Isabel Bermúdez, Timothy C. Gallagher, A. Sofia F. Oliveira
This paper identifies critical receptor-ligand interactions that distinguish varenicline from other nAChR agonists, revealing unique hydrogen bonding interactions essential for its function.
bioRxiv · Jun 14, 2025 · PreprintPharmacology & Toxicology