Author
Oxford Brookes UniversityORCID 0000-0001-7692-1509Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
3 papers
Recent·Most cited
Sheenagh Aiken, Daniele Fiorito, Matthew Harper…·A. Sofia F. Oliveira
This paper identifies critical receptor-ligand interactions that distinguish varenicline from other nAChR agonists, revealing unique hydrogen bonding interactions essential for its function.
Franco Viscarra, Teresa Minguez, Isabel Bermúdez, Philip Charles Biggin
This study identifies how TC-2559, a super-agonist, modulates the high sensitivity nicotinic acetylcholine receptor through both orthosteric and allosteric binding sites, enhancing channel opening.
Max Epstein, Susan Maxwell, Thomas J. Piggot…·Philip Charles Biggin
The paper identifies structural residues in the δ subunit of human muscle nicotinic acetylcholine receptors that influence subunit assembly and functional dynamics.