The paper identifies gene expression changes in brain regions associated with chronic pain, highlighting BLA microglia as a key cell type and finding distinct gene expression patterns compared to other pain-related traits.

Pain · Jul 7, 2025Peer-reviewedGenetic & Genomic Medicine

Decoding the transcriptomic signatures of psychological trauma in human cortex and amygdala

Emily M. Hicks, Carina Seah, Michael Deans, Seo Yeon Lee, Keira J.A. Johnston, Alanna C. Cote, Julia Ciarcia, Akash Chakka, Lily Collier, Paul E. Holtzheimer, Keith A. Young, John Harrison Krystal, Kristen Brennand, Eric J. Nestler, Matthew J. Girgenti, Laura M. Huckins

The paper investigates transcriptional signatures of trauma in human brain regions using RNA-seq data from 304 donors, identifying differential vulnerability of cortical and amygdala regions to different trauma types.

bioRxiv · Oct 23, 2024 · PreprintNeuroscience

Fusing Mobile Phone Sensing and Brain Imaging to Assess Depression in College Students

Jeremy F. Huckins, Alex W DaSilva, Rui Wang, Weichen Wang, Elin L. Hedlund, Eilis I Murphy, Richard B. Lopez, Courtney Rogers, Paul E. Holtzheimer, William M. Kelley, Todd F. Heatherton, Dylan D. Wagner, James V. Haxby, Andrew Thomas Campbell

The paper explores the relationship between smartphone usage patterns and brain connectivity in college students, finding a positive link between screen time and resting-state functional connectivity in regions associated with depression.

Frontiers in Neuroscience · Mar 21, 2019Peer-reviewedNeuroscience