Carina Seah

The paper evaluates estradiol's effects on ASD/NDD genes using human neurons and zebrafish, finding both convergent transcriptomic effects and gene-specific cellular and behavioral rescue.

This study uses a 2D stretch injury model to show that mechanical stretch disrupts calcium dynamics, mitochondrial function, and Piezo1 distribution in human astrocytes, with temporary effects at moderate injury severity.

This paper identifies drug repurposing candidates for chronic pain using genetics and transcriptomics, finding drugs with opposing gene expression effects to the disease.

The paper identifies gene expression changes in brain regions associated with chronic pain, highlighting BLA microglia as a key cell type and finding distinct gene expression patterns compared to other pain-related traits.

The paper identifies BMI-dynamic gene expression loci in the brain and gut, showing how BMI interacts with genetic variants to influence gene expression and disease-related pathways.

The paper investigates transcriptional signatures of trauma in human brain regions using RNA-seq data from 304 donors, identifying differential vulnerability of cortical and amygdala regions to different trauma types.

The paper identifies stress-interactive eQTLs that dysregulate gene expression in the brain under stress, uncovering novel genes linked to brain disorder risk in traumatic stress contexts.

The paper shows that non-additive effects of schizophrenia risk genes are due to convergent downstream transcriptomic effects and sub-additive changes, suggesting functional redundancy as a mechanism for non-additivity.

This study shows that schizophrenia risk genes have convergent and non-additive transcriptomic effects when perturbed together in human neurons, suggesting functional redundancy and complex interactions.