Author

Helena Brezovjakova

Great Ormond Street HospitalORCID 0000-0002-3554-6084Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Amy K. ErbeiD· 1 shared Courtney HimsworthiD· 1 shared Farah AlamiD· 1 shared John AndersoniD· 1 shared Laura DonovaniD· 1 shared Louis ChesleriD· 1 shared Paul M. SondeliD· 1 shared Sophie Munnings-Tomes· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperMolecular Biology

Amy K. ErbeORCID

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1 paper

Recent·Most cited

An optimised method for generation of murine CAR-T cells by CRISPR/Cas9.

Thomas John Jackson, Courtney Himsworth, Sophie Munnings-Tomes, Farah Alam, Helena Brezovjakova, Laura Donovan, Amy K. Erbe, Paul M. Sondel, Louis Chesler, John Anderson

This paper optimizes CRISPR/Cas9 AAV transduction for generating murine CAR-T cells with high efficiency and minimal toxicity, enabling in vivo persistence and pre-clinical testing.

bioRxiv · Nov 29, 2025 · PreprintMolecular Biology