Laura Donovan

This paper optimizes CRISPR/Cas9 AAV transduction for generating murine CAR-T cells with high efficiency and minimal toxicity, enabling in vivo persistence and pre-clinical testing.

The paper evaluates how the functional avidity of anti-B7H3 CAR-T constructs relates to their ability to trigger effector function against tumors with varying antigen density.

This study shows that combining radiation with Bcl-xL inhibition reduces tumor growth in preclinical models of H3K27M-altered diffuse midline glioma.

This study generates human cerebellar organoids to model medulloblastoma subgroups G3 and G4, showing their ability to sustain tumor growth and respond to anti-tumour compounds.