Single-cell RNA-seq reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress
Audrey P. Gasch, Feiqiao Brian Yu, James Hose, Leah E. Escalante, Michael Place, Rhonda L. Bacher, Jad N. Kanbar, Doina Ciobanu, Laura Sandor, Igor V. Grigoriev, Christina M. Kendziorski, Stephen R. Quake, Megan N. McClean
The paper uses single-cell RNA-seq to study stress response heterogeneity in yeast, finding regulatory variation and decoupled transcription-factor activation.
PLoS Biology · Dec 14, 2017Peer-reviewedSystems Biology