HTLV-1 Splice Sites in Prevalent Gene VectorsCause Splicing Perturbations in Transgenic Human Cells
Csaba Miskey, Sabrina Prommersberger, Katrin Mestermann, Michael Hudecek, Zoltán Ivics
This study identifies HTLV-1 splice sites in gene vectors causing splicing perturbations in transgenic human cells and shows that modifying these sites can enhance genomic safety without compromising therapeutic efficacy.
bioRxiv · Jan 28, 2023 · PreprintGenomics