Michael Hudecek

Profound CD4+ T-Cell Reprogramming by Melphalan-Driven Oxidative Stress in High-Risk Multiple Myeloma

This study shows that melphalan treatment causes oxidative stress in T cells, reducing CD4+ naive T cells in high-risk multiple myeloma patients.

Antigen receptor competition in CAR-TCR cells changes cytotoxicity outcomes upon spatial antigen separation

The paper investigates how spatial separation of antigens affects cytotoxicity in CAR-TCR cells by analyzing clonotype dynamics and functional TCR contributions.

A novel CAR T cell blend targeting PDPN and GD2 to overcome glioblastoma heterogeneity

This paper develops a PDPN- and GD2-targeting CAR T cell blend to overcome glioblastoma heterogeneity, showing improved anti-tumor activity in organoids and increased survival in mice.

Tumour-derived glucocorticoids amplify ROR1 and are exploited with glucocorticoid-resistant ROR1 CAR-T cells

The paper shows that tumor-derived glucocorticoids increase ROR1 expression while suppressing T cell activity, and GC-resistant CAR-T cells can overcome this by preserving ROR1 expression in tumor cells.

Metabolization of microbial postbiotic pentanoate drives anti-cancer CAR T cells

This study shows that pentanoate, a microbial postbiotic, is metabolized to citrate, which influences T cell differentiation and anti-cancer CAR T cell efficacy through epigenetic mechanisms.

HTLV-1 Splice Sites in Prevalent Gene VectorsCause Splicing Perturbations in Transgenic Human Cells

This study identifies HTLV-1 splice sites in gene vectors causing splicing perturbations in transgenic human cells and shows that modifying these sites can enhance genomic safety without compromising therapeutic efficacy.