Liam James Elgaard Quinn

Combining genome-wide polygenic scores with registry data for colorectal cancer risk-based screening

This study evaluates polygenic risk scores (PRS) for colorectal cancer (CRC) screening, showing they stratify risk independently of ancestry and sex but offer limited additional predictive value when combined with FIT.

Incorporating phenotype heterogeneity in disease GWAS improves power while maintaining specificity

StratGWAS improves GWAS power by incorporating phenotype heterogeneity while maintaining specificity, identifying more significant loci in depression and other traits.

Genome-wide associations spanning 194 in-hospital drug dosage change phenotypes highlight diverse genetic backgrounds in concurrent drug therapy

This study identifies 51 genome-wide significant loci associated with dosage changes in 42 drug pair phenotypes, revealing distinct genetic patterns in polypharmacy.

Extensive population structure highlights an apparent paradox of stasis in the impala (Aepyceros melampus)

This study sequenced impala genomes to investigate evolutionary stasis, finding genetic structure and reduced natural selection in eastern populations compared to southern African ones.

Population Structure and Migration in the Eastern Highlands of Papua New Guinea; a Region Impacted by the kuru Epidemic

The paper analyzes population genetics in the Eastern Highlands of Papua New Guinea using genome-wide data, revealing genetic structure, admixture events, and evidence of female-biased migration linked to the kuru epidemic.