Ida Moltke

Genomic impact of the second plague pandemic on three human populations

This study analyzes ancient DNA from three European sites to assess the genomic impact of the second plague pandemic, finding no strong positive selection but evidence of reduced long-range immigration post-pandemic.

From deserts to forests: sequencing of the giant forest hog completes the genomic history of the African Suids

This paper presents the first whole-genome data for the giant forest hog, revealing its evolutionary relationship with warthogs and significant genetic differentiation between populations.

Genetic regulation of the plasma proteome and its link to cardiometabolic disease in Greenlandic Inuit

This study identifies 251 genetic variants influencing plasma proteins in Greenlandic Inuit, revealing population-specific associations with cardiometabolic disease.

Detecting epidemic-driven selection: a simulation-based tool to optimize sampling design and analysis strategies

This paper introduces a simulation framework to detect epidemic-driven selection by optimizing sampling design and analysis strategies.

Insufficient evidence for natural selection associated with the Black Death

This paper refutes claims of strong natural selection during the Black Death by showing statistical and technical flaws in the original analysis.

Type 2 diabetes polygenic risk score demonstrates context-dependent effects and associations with type 2 diabetes-related risk factors and complications across diverse populations

Extensive population structure highlights an apparent paradox of stasis in the impala (Aepyceros melampus)

This study sequenced impala genomes to investigate evolutionary stasis, finding genetic structure and reduced natural selection in eastern populations compared to southern African ones.

Population Structure and Migration in the Eastern Highlands of Papua New Guinea; a Region Impacted by the kuru Epidemic

The paper analyzes population genetics in the Eastern Highlands of Papua New Guinea using genome-wide data, revealing genetic structure, admixture events, and evidence of female-biased migration linked to the kuru epidemic.

An LDLR missense variant poses high risk of familial hypercholesterolemia in 30% of Greenlanders and offers potential for early cardiovascular disease intervention

The paper investigates the impact of the LDLR p.G137S variant on metabolic health and cardiovascular disease risk in Greenlanders, finding it increases FH and cardiovascular disease risk in up to 30% of the population.

NGSremix: A software tool for estimating pairwise relatedness between admixed individuals from next-generation sequencing data

NGSremix estimates pairwise relatedness in admixed individuals from low-depth NGS data, outperforming existing methods by accounting for genotype uncertainty.

Mapping the human genetic architecture of COVID-19 by worldwide meta-analysis

This study identifies 13 genome-wide significant loci associated with SARS-CoV-2 infection or severe COVID-19 through a global meta-analysis of 49,562 patients.

Population genomics of the Viking world

This study analyzes ancient genomes from the Viking Age to understand genetic structure and migration patterns, finding significant foreign gene flow and population differentiation.

Ancestry-specific association mapping in admixed populations

This paper introduces a statistical method for association testing in admixed populations that allows ancestry-dependent effect sizes, improving power to detect associations and helping identify causal SNPs.

Allele frequency-free inference of close familial relationships from genotypes or low depth sequencing data

This paper introduces a method to infer close familial relationships from genotypes or low-depth sequencing data without requiring allele frequencies or genomic positions, showing comparable accuracy to existing methods.

Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits

The paper performs deep whole genome sequencing on 1,457 individuals to investigate rare variant contributions to cardiometabolic traits, identifying new regulatory variants and gene-trait associations.

Extreme distribution of deleterious variation in a historically small and isolated population-insights from the Greenlandic Inuit

This study analyzes exome sequencing data from Greenlandic Inuit to show they have a severe genetic bottleneck leading to an extreme distribution of deleterious alleles and higher genetic load compared to other populations.