David Samuel DiCapua Siegel

Genetic Ethnicity and Hypertension Epistatic Interaction Underlying Racial Disparities in US Multiple Myeloma Susceptibility

The paper identifies an epistatic interaction between genetic ethnicity and hypertension that explains racial disparities in multiple myeloma risk among Black and mixed-ancestry individuals.

Genomic Basis of Multiple Myeloma Subtypes from the MMRF CoMMpass Study

The paper identifies genomic subtypes of multiple myeloma using the MMRF CoMMpass study and finds that 25.5% of patients transition to a high-risk expression subtype at progression, which expresses immunotherapy targets.

Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs

The paper maps allele-specific DNA methylation in normal and cancer tissues, identifying disease-associated regulatory SNPs that are missed by other methods.