Prasad Kasturi

The paper identifies age-associated aggregation-prone proteins in C. elegans and evaluates phytochemicals targeting conserved proteins, finding quercetin as a strong binder but no significant effect on protein insolubility.

This study performs a meta-analysis of age-dependent changes in extracellular vesicle proteins in C. elegans, revealing age-related abundance changes, aggregation, and overlap with Alzheimer's disease-related proteins.

The study identifies age-regulated secreted proteins in C. elegans that affect lifespan when their abundance is altered, suggesting their role in proteostasis and aging.