Jakub K. Famulski

Zebrafish prph2a/b and rom1a/b serve distinct functions during cone and rod outer-segment assembly.

This study investigates the distinct roles of prph2a/b and rom1a/b in zebrafish photoreceptor outer-segment assembly, showing prph2a/b are critical for cone OSs while rom1a/b are essential for rod OSs.

Glutamine-Dependent Slc25a39-Nrf2 Axis Couples Mitochondrial Dynamics with Metabolic Reprogramming to Establish Myogenic Commitment

Cdhr1a and pcdh15b link photoreceptor outer segments with inner segment calyceal processes revealing a potential mechanism for cone-rod dystrophy.

Zebrafish anterior segment mesenchyme progenitors are defined by function of tfap2a but not sox10.

The paper identifies tfap2a as critical for anterior segment mesenchyme specification in zebrafish, while sox10 is dispensable for this process.

Temporal single cell transcriptome atlas of zebrafish anterior segment development reveals high degree of conservation between the trabecular meshwork and the annular ligament

The paper constructs a temporal single-cell transcriptome atlas of zebrafish anterior segment development, revealing conservation with mammalian trabecular meshwork and corneal tissues.

Proteasome-mediated regulation of Cdhr1a by Siah1 modulates photoreceptor development and survival in zebrafish.

This study shows that Siah1 regulates Cdhr1a via the proteasome, affecting photoreceptor development and survival in zebrafish.

Pax2a regulates angiogenesis to facilitate mmp2-dependent basement membrane remodeling of the optic fissure

The paper shows Pax2a regulates angiogenesis and basement membrane remodeling in the optic fissure by modulating Adamts1 and MMP2 expression in zebrafish.

Spatiotemporal characterization of periocular mesenchyme heterogeneity during anterior segment development

This study characterizes the heterogeneity of periocular mesenchyme during zebrafish anterior segment development using in vivo imaging and transcriptomic analysis.