Glutamine-Dependent Slc25a39-Nrf2 Axis Couples Mitochondrial Dynamics with Metabolic Reprogramming to Establish Myogenic Commitment
Brian Kelly, Chia-Hua Wu, Kaan Ihsan Eskut…·Chintan K. Kikani
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National Institutes of HealthORCID 0000-0003-2348-2332Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Brian Kelly, Chia-Hua Wu, Kaan Ihsan Eskut…·Chintan K. Kikani
Mamduh Khateb, Jelena Perovanović, Kyung Dae Ko…·Vittorio Sartorelli
This study uses bulk and single-cell assays to analyze gene expression, histone modifications, and chromatin features in ESCs transitioning to mesoderm lineages, identifying cis-regulatory elements and transcription factors involved in lineage specification.
Jelena Perovanović, Yifan Wu, Hosiana Abewe…·Dean R Tantin
This study shows that Oct1 works with Smad factors to activate mesodermal genes during differentiation, improving understanding of lineage specification.