Dean R Tantin

The paper characterizes thymic adipocyte heterogeneity and metabolic signatures in mice, identifying two distinct subpopulations with distinct transcriptional and chromatin features.

The paper identifies Jade1 as a cofactor of Oct4 that selectively interacts with specific DNA configurations to enhance histone acetylation and transcriptional regulation.

This study shows OCA-B in T cells promotes ICI-induced autoimmunity but is not needed for anti-tumor immunity, suggesting it could be targeted to prevent autoimmunity without harming cancer treatments.

This study identifies OCA-B as a driver of pathogenic maturation in stem-like CD4+ T cells, promoting autoimmune demyelination in multiple sclerosis.

This study identifies a redox-sensitive cysteine residue in Oct4 that regulates reprogramming and differentiation by affecting DNA binding and ubiquitylation.

This study shows that Oct1 works with Smad factors to activate mesodermal genes during differentiation, improving understanding of lineage specification.