A human DCC variant causing mirror movement disorder reveals an essential role for the Wave regulatory complex in Netrin/DCC signaling
Karina Chaudhari, Kaiyue Zhang, Patricia T. Yam, Yixin Zang, Daniel A. Kramer, Sabrina Schlienger, Sara Calabretta, Meagan Collins, Myriam Srour, Baoyu Chen, Frédéric Charron, Greg J. Bashaw
This paper identifies a DCC variant causing mirror movement disorder and shows it disrupts the DCC-WAVE regulatory complex interaction, essential for Netrin-1 signaling.
bioRxiv · Oct 13, 2022 · PreprintNeuroscience