Frédéric Charron

This study identifies a Netrin-1 signaling pathway that regulates muscle stem cell protrusion dynamics and quiescence maintenance through cytoskeletal components.

This study identifies DNA-PK as a synthetic lethal target in TP53-deficient SHH medulloblastoma, showing that inhibiting DNA-PK enhances radiosensitivity and improves survival in preclinical models.

This study shows Numb is required for Shh-mediated repulsion of retinal ganglion cell and spinal commissural axons, highlighting its role in both attraction and repulsion processes.

This paper identifies a DCC variant causing mirror movement disorder and shows it disrupts the DCC-WAVE regulatory complex interaction, essential for Netrin-1 signaling.