Daniel A. Kramer

Phosphoinositide regulation by the CCC complex promotes phagosome maturation and host defense

This study shows that the CCC complex regulates PI(3)P levels on phagosomal membranes, which is critical for phagosome maturation and antibacterial immunity.

Toxoplasma effector TgWIP hijacks dendritic cell actin and motility via Nck1/Grb2 and the WAVE complex

This study identifies TgWIP interactions with Nck1/Grb2 and the WAVE complex to reveal how Toxoplasma manipulates host cell actin dynamics and motility.

The Rab32-LRMDA-Retriever Complex is a Key Regulator of Intestinal Immune Homeostasis

This study identifies the Rab32-LRMDA-Retriever complex as essential for endolysosomal trafficking in innate immune cells, maintaining intestinal immune homeostasis.

Light-guided actin polymerization drives directed motility in protocells

This study demonstrates light-controlled actin polymerization in protocells, enabling directed motility and revealing the role of branched and linear actin networks in membrane protrusion.

A human DCC variant causing mirror movement disorder reveals an essential role for the Wave regulatory complex in Netrin/DCC signaling

This paper identifies a DCC variant causing mirror movement disorder and shows it disrupts the DCC-WAVE regulatory complex interaction, essential for Netrin-1 signaling.