Prolyl hydroxylation is required for maturation and secretion of Zika virus non-structural protein 1
Bodine Bezemer, Gijs J. Overheul, Milou Stevens, Cornelia G. Spruijt, Michiel Vermeulen, Pascal Miesen, Ronald P. van Rij
This study identifies prolyl hydroxylation as essential for ZIKV NS1 maturation and secretion, with mutations affecting viral replication and protein stability.
bioRxiv · Jul 17, 2026 · PreprintMicrobiology