Pascal Miesen

This study shows that Piwi5 is essential for piRNA production and transposon silencing in Ae. albopictus, with loss of Piwi5 leading to increased transposon activity.

This study shows that Piwi6 in Aedes mosquitoes suppresses LTR retrotransposons in both gonadal and somatic tissues by guiding H3K9me3 histone deposition.

This study shows that a non-retroviral EVE suppresses viral replication in mosquitoes across life stages and generations but does not affect survival or reproduction.

This study identifies prolyl hydroxylation as essential for ZIKV NS1 maturation and secretion, with mutations affecting viral replication and protein stability.

The paper identifies potential ambiguities in glycoRNA analysis by showing that RNase sensitivity of glycosylated RNA species depends on purification methods, suggesting co-purification of non-glycoRNA glycoconjugates.

This study challenges the assumed antiviral role of Vago genes in Aedes aegypti by showing that VLG-1 has a modest proviral effect during DENV and ZIKV infections.

This study uses PRO-seq to profile nascent transcription in Aedes aegypti, identifying regulatory elements and dynamic immune responses to bacterial stimulation.

This study identifies Dhx15 as a host factor that controls glycolysis and arbovirus replication in Aedes aegypti cells by modulating gene expression.

The paper investigates how endogenous piRNAs guide slicing of viral RNA in Aedes aegypti mosquitoes, leading to the production of responder and trailer piRNAs.

The paper identifies a piRNA-lncRNA regulatory network in Aedes aegypti mosquitoes that initiates responder and trailer piRNA formation during embryonic development.

The paper presents an improved genome assembly of Aedes albopictus, revealing new biological features and enabling population and developmental studies.

The paper identifies abundant viral integrations in Aedes aegypti and Ae. albopictus genomes that express piRNAs, suggesting a functional link to the piRNA pathway and antiviral defense.