Interference with MHC class I epitope trimming provides paradoxical protection from autoimmune diabetes
Barbara Bertocci, Emmanuelle Waeckel-Énée, Nadia Keelan, Sylvaine You, Pierre David, Peter Van Endert
The paper shows that reducing MHC class I epitope trimming in NOD mice delays diabetes by altering T cell responses and epitope presentation.
bioRxiv · Feb 20, 2026 · PreprintImmunology