Tim R. Zacharewski

This study shows TCDD exposure causes dose-dependent changes in mouse urinary metabolites linked to AHR-mediated gene expression in the liver.

This paper introduces scVIDR, a variational autoencoder for predicting dose-dependent gene expression in single cells across different cell types and tissues, showing improved performance over existing methods.

This study benchmarks Bayesian and frequentist methods for differential gene expression analysis in dose-response scRNA-seq studies, finding that multi-group methods outperform two-group approaches.

This study uses single nuclei RNA sequencing to identify cell-specific transcriptional changes and population shifts in mouse liver exposed to TCDD, revealing increased macrophages and RAS signaling in nonparenchymal cells.