Jack R. Harkema

This study shows that combining docosahexaenoic acid (DHA) with prednisone (PDN) better maintains remission in preclinical lupus nephritis than either treatment alone.

This study shows H5N1 influenza virus can be transmitted vertically through placental and mammary routes in pregnant mice, causing developmental impairments in offspring.

This study identifies sex differences in long COVID sequelae in mice, showing that X-linked genes like Xist and Tlr7 contribute to persistent inflammation and cognitive impairments in females.

This study identifies alveolar macrophages as critical for ozone tolerance in mice, showing their role in reducing inflammation and injury through suppressed signaling pathways.

This study shows TCDD exposure causes dose-dependent changes in mouse urinary metabolites linked to AHR-mediated gene expression in the liver.

This paper develops a mouse model of SARS-CoV-2 BA.5 infection that induces fibrotic lung disease and tertiary lymphoid structures, enabling study of acute and post-acute sequelae of COVID-19.

This study shows that omega-3 fatty acids and glucocorticoids synergistically suppress inflammatory gene expression in SLE macrophages, promoting a pro-resolving M2 phenotype and potentially reducing steroid dependence.

This study designs miniproteins that inhibit MERS-CoV by targeting the spike protein, showing broad neutralization and protective efficacy in mice.