Author

Gregory Parsonage

University of LeedsORCID 0000-0002-3666-5288Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:development & morphogenesis· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

David J. BeechiD· 2 shared Laeticia LichtensteiniD· 2 shared Charalampos Konstantinou· 1 shared Chew Weng ChengiD· 1 shared Elizabeth AV Jones· 1 shared Elizabeth Evans· 1 shared Eulashini Chuntharpursat‐BoniD· 1 shared Fiona BartoliiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersPhysiology

David J. BeechORCID

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2 papers

Recent·Most cited

PhysiologyAtherosclerosisPeer-reviewedAug 1, 2024

PIEZO1 force sensing controls global lipid homeostasis

Laeticia Lichtenstein, Chew Weng Cheng, Elizabeth Evans…·David J. Beech

This study shows that endothelial PIEZO1 force sensing regulates lipid homeostasis by affecting cholesterol metabolism and excretion, with implications for hyperlipidaemia.

DOI 10.1016/j.atherosclerosis.2024.118511

mousehuman

𝕏 PostBluesky

Cell BiologybioRxivPreprintAug 12, 2019

Piezo1 channel activates ADAM10 sheddase to regulate Notch1 and gene expression

Vincenza Caolo, Marjolaine Debant, Naima Endesh…·David J Beech

The paper shows that Piezo1 channels activate ADAM10 to regulate Notch1 cleavage and gene expression in response to mechanical force.

DOI 10.1101/732370

mouseproteomics

𝕏 PostBluesky