The Core Subunit NDUFS2 in Mitochondrial Electron Transport Chain Complex I is Critical to Oxygen Responsiveness of Human Ductus Arteriosus Smooth Muscle Cells
Rachel E. T. Bentley, Kimberly J. Dunham‐Snary, Ashley Y Martin, Jeffrey D. Mewburn, Asish Dasgupta, Kuang‐Hueih Chen, Benjamin P. Ott, Tanvi Nandani, Bernard Thébaud, Mark Kevin Friedberg, Charles C.T. Hindmarch, Stephen L. Archer
This paper shows that NDUFS2 in mitochondrial Complex I is critical for oxygen responsiveness in human DASMCs, affecting calcium, cell shortening, and mROS without altering respiration.
bioRxiv · Jul 8, 2025 · PreprintMolecular Biology