The experimental design and data interpretation in “Unexpected mutations after CRISPR–Cas9 editing in vivo” by Schaefer et al. are insufficient to support the conclusions drawn by the authors
Christopher J. Wilson, Tim J. Fennell, Anne Bothmer, Morgan L. Maeder, Deepak Reyon, Cecilia Cotta‐Ramusino, Cecilia A. Fernández, Eugenio Marco, Luis Alberto Barrera, Hariharan Jayaram, Charles F. Albright, Gerald F. Cox, George McDonald Church, Vic E. Myer
The paper critiques the experimental design and data interpretation in a previous study claiming CRISPR-Cas9 causes unexpected mutations, arguing the conclusions are not supported by the evidence.
bioRxiv · Jul 10, 2017 · PreprintGenetics