Nicholas Paul Gauthier

This study uses evolutionary models to design highly divergent protein variants with enhanced functional properties while maintaining structure.

The paper develops a temporal modeling framework to link protein changes to drug responses in melanoma cells, identifying effective therapies through experimental validation.

AlignmentViewer provides a web-based tool for visualizing and analyzing large protein family alignments, supporting evolutionary coupling analysis and 3D structure computation.

The paper uses genetic epistasis experiments to predict 3D protein structures with 86% accuracy for residue contacts and generates models within 2.4 Å of known structures for small proteins.

The paper evaluates the Zeptosens RPPA platform for protein profiling in cancer samples, demonstrating its sensitivity, reproducibility, and accuracy.