Xiaohong Jing

Clonal Heterogeneity in Human Pancreatic Ductal Adenocarcinoma and Its Impact on Tumor Progression

This study analyzes clonal heterogeneity in human pancreatic ductal adenocarcinoma using single-cell and spatial transcriptomics, revealing transcriptional continua, clonal transitions, and spatially dispersed clones associated with metastasis.

Perturbation biology links temporal protein changes to drug responses in a melanoma cell line

The paper develops a temporal modeling framework to link protein changes to drug responses in melanoma cells, identifying effective therapies through experimental validation.

Enhanced specificity of high sensitivity somatic variant profiling in cell-free DNA via paired normal sequencing: design, validation, and clinical experience of the MSK-ACCESS liquid biopsy assay

The paper describes the development and clinical application of MSK-ACCESS, a liquid biopsy assay that improves the specificity of somatic variant detection in cell-free DNA by using paired normal sequencing.

Protein Profiling In Cancer Cell Lines And Tumor Tissue Using Reverse Phase Protein Arrays

The paper evaluates the Zeptosens RPPA platform for protein profiling in cancer samples, demonstrating its sensitivity, reproducibility, and accuracy.

Perturbation biology models predict c-Myc as an effective co-target in RAF inhibitor resistant melanoma cells

The paper uses perturbation biology to predict c-Myc as a co-target with BRAF/MEK inhibitors to overcome RAF inhibitor resistance in melanoma.