Floyd H. Chilton

Parallel multiOMIC analysis reveals glutamine deprivation enhances directed differentiation of renal organoids

This study shows that glutamine deprivation promotes podocyte maturation in renal organoids through metabolic and transcriptomic changes during differentiation.

Identification of an allele-specific transcription factor binding interaction that regulates PLA2G2A gene expression

The paper identifies an allele-specific SP1 binding interaction at rs11573156 that influences PLA2G2A expression across multiple tissues.

Amerind ancestry predicts the impact of FADS genetic variation on omega-3 PUFA deficiency, cardiometabolic and inflammatory risk in Hispanic populations

The paper shows Amerind ancestry is linked to lower LC-PUFA levels and increased cardiometabolic risk in Hispanic populations due to FADS genetic variation.

Acyl-lipid desaturases and Vipp1 cooperate in cyanobacteria to produce novel omega-3 PUFA-containing glycolipids

This paper demonstrates that engineering cyanobacteria with specific desaturases and Vipp1 produces novel omega-3 PUFA-containing glycolipids, offering sustainable sources of anti-inflammatory nutrients.