Martha L. Daviglus

Association of polygenic risk scores with low-density lipoprotein cholesterol levels and control: findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

This study evaluates polygenic risk scores (PRS) for LDL cholesterol in a diverse Hispanic/Latino population, finding that some PRS improve prediction across subgroups but statin effectiveness varies with genetic ancestry.

Relation of Self-Reported Race and Genetic Ancestry to Hypertension Prevalence Among Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos

The paper examines the relationship between self-reported race, genetic ancestry, and hypertension prevalence among Hispanics/Latinos using the HCHS/SOL dataset.

Insomnia-Related Metabolomic Profiles Reflect Antioxidant Deficits and Relate to Cognitive Decline Through a Metabolic Risk Score in HCHS/SOL

This study identifies metabolites linked to insomnia symptoms and develops risk scores predicting cognitive decline in Hispanic/Latino adults.

Old vs. New Local Ancestry Inference in HCHS/SOL: A Comparative Study

This study compares old and new local ancestry inference methods in Hispanic/Latino populations using HCHS/SOL data, finding high similarity but some regional discrepancies.

Differential prediction performance between Caribbean- and Mainland-subgroups using state-of-the-art polygenic risk scores for coronary heart disease: Findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

This study evaluates polygenic risk scores for coronary heart disease in Hispanic/Latino subgroups, finding better performance in Mainland compared to Caribbean subgroups.

The frequency of pathogenic variation in the All of Us cohort reveals ancestry-driven disparities

The paper analyzes pathogenic variant frequencies in the All of Us cohort by ancestry, revealing disparities and potential biases in genomic data.

Multi-ancestry genome-wide association study improves resolution of genes, pathways and pleiotropy for lung function and chronic obstructive pulmonary disease

This study performs a multi-ancestry GWAS on lung function and COPD, identifying 559 genes and 29 pathways, and showing genetic risk scores are associated with COPD across ancestries.

An integrated multi-omics analysis of sleep-disordered breathing traits across multiple blood cell types

The paper integrates multi-omics data to analyze how sleep-disordered breathing traits affect gene expression, metabolites, and potential causal pathways across blood cell types.

Admixture mapping screening of CKD traits and risk factors in U.S. Hispanic/Latino individuals from Central America country-of-origin

The paper identifies ancestry-derived loci associated with CKD traits and risk factors in U.S. Hispanic/Latino individuals of Central American origin using admixture mapping.

Amerind ancestry predicts the impact of FADS genetic variation on omega-3 PUFA deficiency, cardiometabolic and inflammatory risk in Hispanic populations

The paper shows Amerind ancestry is linked to lower LC-PUFA levels and increased cardiometabolic risk in Hispanic populations due to FADS genetic variation.

Genome-wide admixture mapping of eGFR and CKD identify European and African ancestry-of-origin loci in U.S. Hispanics/Latinos

This study uses admixture mapping to identify ancestry-specific loci associated with eGFR and CKD in U.S. Hispanics/Latinos and validates findings in African Americans.

Polygenic Risk Scores for Alzheimer's Disease and Mild Cognitive Impairment in Hispanics/Latinos in the U.S: The Study of Latinos - Investigation ofNeurocognitive Aging

The paper evaluates polygenic risk scores for Alzheimer's Disease and Mild Cognitive Impairment in Hispanics/Latinos, finding that PRS based on AD GWAS predict MCI, with APOE region SNPs driving the association.