Rajasree Menon

The paper integrates multiple single-cell and single-nucleus RNA-sequencing datasets to create a comprehensive Human Kidney Cell Atlas, identifying cell types, states, and disease-associated populations.

This study shows dapagliflozin reduces hypoxia-induced metabolic stress, cell death, and fibrosis in kidney organoids derived from human pluripotent stem cells.

The paper presents a multi-modal atlas of human kidney disease, identifying cellular and spatial mechanisms of injury resolution or failure and linking them to clinical outcomes.

This paper describes the construction and usage of the Human Reference Atlas (HRA) v2.0, which integrates multiscale data across 36 organs and provides tools for analysis and visualization.

This paper benchmarks multimodal single-cell data integration methods to improve kidney reference atlas quality by identifying adaptive states and rare cell types.

This study shows that glutamine deprivation promotes podocyte maturation in renal organoids through metabolic and transcriptomic changes during differentiation.

The paper creates a high-resolution cellular atlas of healthy and injured kidney cell states and niches using single-cell and spatial technologies, identifying molecular signatures and pathways related to kidney injury.

The paper constructs a reference tissue atlas of the human kidney using multi-omics data to identify cell types, pathways, and genes across nephron segments and interstitium.

The paper develops a pipeline combining micro-dissection and long/short-read sequencing to identify compartment-specific isoforms in kidney tissue, finding distinct isoform expression in glomerular and tubulo-interstitial compartments.

The paper identifies a transcriptional signature of glomerular disease using single-cell profiling of human kidney organoids and validates it in disease cohorts.

This study identifies 16 genome-wide significant loci associated with diabetic kidney disease, including a protective variant in the COL4A3 gene.

This study uses single-cell transcriptomics to analyze human fetal kidney development, identifying 17 cell clusters and their lineage trajectories.

The paper identifies eQTLs in glomerular and tubulointerstitial kidney tissues from nephrotic syndrome patients, finds tissue-specific eQTLs, and integrates them with a GWAS to identify associated genes.

This paper develops a probabilistic method to model functional relationships at the splice isoform level by integrating heterogeneous genomic data in mice, revealing isoform-specific interactions and functional diversity.