Katarzyna Dorota Raczyńska

Waking the sleepers: lincRNA overexpression compromises DHX36 activity and global protein synthesis

This study shows that overexpression of testis-enriched lincRNAs in somatic cells reduces DHX36 activity and global protein synthesis, leading to cellular dysfunction.

Novel function of U7 snRNA in the repression of HERV1/LTR12s and lincRNAs in human cells

This study identifies a novel role for U7 snRNA in repressing HERV1/LTR12s and lincRNAs by inhibiting NF-Y transcription factor binding, suggesting a protective function in silencing genetic elements in specific cell types.

FUS modulates the level of ribosomal RNA modifications by regulating a subset of snoRNA expression

This study shows FUS regulates snoRNA expression, affecting rRNA modifications like 2-O-Me and pseudouridylation, which may contribute to ALS pathology.

FUS controls the processing of snoRNAs into smaller RNA fragments that can regulate gene expression

The paper shows FUS regulates snoRNA processing into sdRNAs, which can influence gene expression and may serve as biomarkers.