Targeting Pleiotrophin to mitigate high fat diet-induced liver metabolic disease: Insights into sex-specific metabolic protection.
Héctor Cañeque‐Rufo, Agata Zuccaro, Marta Inmaculada Sanz-Cuadrado, Federica Ruin, Ángela Olivera-Rodriguez, Javier Pizarro‐Delgado, María Limones, Jimena Pita, María Gracia Sánchez‐Alonso, Julio Sevillano, Ángela M. Valverde, Esther Gramage, Gonzalo Herradón, Pilar Ramos
This study shows that deleting Pleiotrophin (PTN) protects against high-fat diet-induced liver disease and reveals sex-specific metabolic differences, with females showing greater protection.
bioRxiv · Dec 2, 2025 · PreprintBiochemistry