Author

Kala K. Mahen

Cleveland ClinicORCID 0000-0002-3739-6972Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:metabolism & bioenergetics· 3 Approach:experimental assay· 2 Assay:metabolomics· 2 Organism:mouse· 2 Assay:behavioral assay· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

Adeline M. HajjariD· 3 shared Amy C BurrowsiD· 3 shared Anthony J. HorakiD· 3 shared Jonathan Mark BrowniD· 3 shared Marko MrdjeniD· 3 shared Mohammed DwidariD· 3 shared Naseer SangwaniD· 3 shared Nour MouannesiD· 3 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Adeline M. HajjarORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Gut Microbe-Derived N-Acyl Serinol Lipids Shape Host Postprandial Metabolic Homeostasis

Sumita Dutta, Kala K. Mahen, William J. Massey, Venkateshwari Varadharajan, Amy C Burrows, Anthony J. Horak, Marko Mrdjen, Nour Mouannes, Danny Orabi, Lucas J. Osborn, Treg M. Grubb, Rachel C. Hohe, Rakhee Banerjee, Vinayak Uppin, Dev Laungani, , Jonathan Mark Brown

This study identifies N-acyl amides from gut microbes as regulators of postprandial metabolic homeostasis by affecting host hormones, gene expression, and microbiome composition.

Proceedings of the National Academy of Sciences · Mar 19, 2026Peer-reviewedPhysiology

Multi-Omic Analyses of Dietary Fatty Acid-Microbe-Host Interactions Reveal Metaorganismal Lipid Metabolic Crosstalk Impacting Cardiometabolic Disease

Nour Mouannes, Amy C Burrows, Anthony J. Horak, Venkateshwari Varadharajan, Sumita Dutta, Kala K. Mahen, Rakhee Banerjee, William J. Massey, Xiayan Ye, Marko Mrdjen, Amanda L. Brown, Olumuyiwa Awoniwi, Kohey Kitao, Adarsh Sandhu, Chiaki Tomimoto, , Jonathan Mark Brown

This study investigates how dietary fatty acids interact with gut microbiota and host metabolism to influence lipid homeostasis and cardiometabolic disease in mice.

bioRxiv · Feb 18, 2026 · PreprintBiochemistry

Gut Microbe-Derived Trimethylamine Shapes Circadian Rhythms Through the Host Receptor TAAR5

Kala K. Mahen, William J. Massey, Danny Orabi, Amanda L Brown, Thomas C. Jaramillo, Amy C Burrows, Anthony J. Horak, Sumita Dutta, Marko Mrdjen, Nour Mouannes, Venkateshwari Varadharajan, Lucas J. Osborn, Xiayan Ye, Dante M Yarbrough, Treg M. Grubb, , Jonathan Mark Brown

This study shows that gut microbe-derived TMA affects circadian rhythms through the host receptor TAAR5, impacting metabolism and behavior in mice.

bioRxiv · Apr 3, 2025Biochemistry