Lucas J. Osborn

This study identifies N-acyl amides from gut microbes as regulators of postprandial metabolic homeostasis by affecting host hormones, gene expression, and microbiome composition.

This study identifies ABHD6 as a therapeutic target in MASLD-related HCC by showing its role in lysosomal lipid remodeling and tumor progression.

This study shows that dietary elderberry extract, through gut microbial conversion to hydrocinnamic acid, improves obesity-related metabolic disorders in mice by enhancing insulin sensitivity and reducing liver fat.

This study shows that gut microbe-derived TMA affects circadian rhythms through the host receptor TAAR5, impacting metabolism and behavior in mice.