NeurosciencebioRxivPreprint
α-synuclein over expression, NRF2 suppression, and enhanced ferroptosis creates a vicious cycle of neuronal loss in Parkinson's disease
Annadurai Anandhan, W Chen, Lan Ngoc-Nguyen…·D.D. Zhang
In Parkinson's disease models, alpha-synuclein overexpression sensitizes neurons to ferroptosis, potentially by suppressing NRF2 protein, while Nrf2 loss increases ferroptosis markers, alpha-synuclein pathology, and behavioral deficits.
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